3D COLLAGEN FIBRILLAR MICROSTRUCTURE GUIDES PANCREATIC CANCER CELL PHENOTYPE AND SERVES AS A CRITICAL DESIGN PARAMETER FOR PHENOTYPIC MODELS OF EMT.

3D collagen fibrillar microstructure guides pancreatic cancer cell phenotype and serves as a critical design parameter for phenotypic models of EMT.

Pancreatic cancer, one of the deadliest cancers, is characterized by high rates of metastasis and intense desmoplasia, both of which are associated with changes in fibrillar type I collagen composition and microstructure.Epithelial to mesenchymal transition (EMT), a critical step of metastasis, also involves a change in extracellular matrix (ECM) c

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RecurIndex assay as an aid for adjuvant chemotherapy decisions in HR-positive HER2-negative breast cancer patients

BackgroundAdjuvant chemotherapy is a major adjuvant treatment modality for hormonal receptor (HR)-positive and HER2-negative early breast cancer, but only 2%-20% of patients derive practical benefits.How to balance its potential benefits and risks becomes a challenging clinical problem.The purpose of this study was to assess whether RecurIndex assa

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Optimization Design of Pressure Hull for Long-Range Underwater Glider Based on Energy Consumption Constraints

Underwater gliders are a class of ocean observation equipment driven by buoyancy, and their energy consumption source is mainly generated by the active regulation of buoyancy.The periodic elastic deformation of the pressure hull during the PANTOTHENIC ACID 250MG upward and downward movement of the underwater glider can have a large impact on its dr

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